Why is error-prone repair useful

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Reference no: EM1398212

1. If a replication error that creates an A-G mismatch is not repaired before the next round of replication, what will be the sequences of the 2 daughter DNAs after replication

2.Transcription-coupled repair occurs more rapidly than global genome repair. Why?

3. Glycosylases flip out damaged bases but Rad4/XPC flips out undamaged bases across from sites of damage. Given the roles of these different proteins, why does this difference make sense?

4.Why is error-prone repair useful, even if it introduces mutations?

5. Cancer cells from patients with HNPCC show dramatic changes in the lengths of microsatellite loci. Explain.

6. Explain why large gaps and double-strand breaks are preferentially repaired by recombination, but a stalled replication fork can utilize either excision repair or recombination-repair pathways.

7.Many lymphoid cancers in patients with diseases such as NBS are linked to chromosomal translocations. Explain.

Reference no: EM1398212

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