Why g-protein linked receptors activate g proteins

Reference no: EM1339731

G-protein linked receptors activate G proteins by reducing the strength of GDP binding. This results in rapid dissociation of bound GDP, which is then replaced by GTP, which is present in the cytosol in much higher concentrations than GDP. What consequences would result from a mutation in the alpha subunit of the G protein that caused its affinity for GDP to be reduced without significantly changing its affinity for GTP? Compare the effects of this mutation with the effects of cholera toxin.

Reference no: EM1339731

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