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Why a vaccine based solely on carbohydrate moieties

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Reference no: EM132520526

1. Unlike immunoglobulins, TCRs do not undergo class switching, suggest a possible reason for that.

2. Explain why a vaccine based solely on Carbohydrate moieties (e.g. capsular polysaccharides) of a bacterial or a fungal pathogen is illogical should the generation of long-term memory be desired.

3. Assume that there is no such thing as DNA rearrangement to generate adaptive immune receptor (TCR and BCR/Igs) diversity, can you suggest / hypothesize alternative mechanisms that could generate high levels of diversity in the TCR/BCR repertoires using limited numbers of genes.

Reference no: EM132520526

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