Who does the problem affect about kidney on a chip

Reference no: EM132312800 , Length: word count : 700

Article- A Fibrin-Based Tissue-Engineered Renal Proximal Tubule for Bioartificial Kidney Devices: Development, Characterization and In Vitro Transport Study By Chee Ping Ng, Yuhang Zhuang.

TOPIC: KIDNEY ON A CHIP

Introduction

Problem Statement

Problem Description (5'W - Who, What, When, Where and Why)

Who does the problem affect?

What is the issue? What is the impact of the issue?

- What impact is the issue causing?

- What will happen when it is fixed?

- What would happen if we didn't solve the problem?

When does the issue occur?

- When does it need to be fixed?

Where is the issue occurring?

Why is it important that we fix the problem?

Clinical Need of the product

• Throughout mammalian species, kidneys play a vital role in the regulation of the blood by filtering waste products and excess nutrients through a variety of membranous interactions.

• These processes are complex and occur on a molecular scale.

• Only around 12% of drugs in clinical trials will reach the market due to problems with pharmacokinetics, efficacy and toxicity

• Current approaches to these problems such as animal testing are expensive, inefficient and are often unreliable due to the disparity between human and animal metabolisms.

• Problem Definition-

• Lack of innovation in methods of nephrotoxicity testing

Reference no: EM132312800

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