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Question 1. Which mammals have been impacted by avian influenza virus? Do you think these species share anything in common that make them more susceptible?
Pigs and Ferrets have been impacted by avian influenza virus .
Question 2. Based on this article, describe an approximate geographic distribution for avian influence in mammals?
Question 3. What is a "gain of function" experiment? Do you agree that they should be restricted?
Question 4. describe how mutations in the following proteins of the H5N1 avian influenza virus could cause a human pandemic.
Hemagglutinin
Nucleoprotein
Polymerase complex
Question 5. What is E627K and how does it relate to PB2?
Question 6. Why would it be particularly alarming if the avian influenza virus was found spreading in pigs?
Question 7. After reading this article, are you concerned that H5N1 will spillover from birds to humans and cause a pandemic? Why or why not?
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