Which alteration of urine ph with urine acidifier

Reference no: EM133603635

Assignment:

May use at least 2 decimal places in expressing the answers

Questions

1. The plasma creatinine of a 50-year old male patient was found to be 2 mg/dL. Over a 24-hour period, 1250mL of urine was collected and the concentration of creatinine in urine was found to be 170 mg/dL. What is the CrCl of the patient and what is the status of his kidney function?

2. Describe situations in which alteration of urine pH with urine acidifier or alkalinizing agents can be used to enhance the clinical response of other drugs.

3. Penicillin G is completely excreted unchanged in the urine, and studies have shown that probenecid given concurrently causes elevation of the serum penicillin G concentration. What is the probable mechanism for the interaction of probenecid with penicillin G? Clue: Choose among the mechanisms of renal drug excretion.

Reference no: EM133603635

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