User Account

All Pages

Where did the block in the tca cycle occur

Assignment Help Biology
Reference no: EM132439749

Problem: Fluoroacetate, which is used for rodent control, is also produced by a South African plant.  After entering a cell, fluoroacetate is converted to fluroacetyl-CoA in a reaction catalyzed by the enzyme acetate thiokinase:

F-CH2COO- + CoA-SH + ATP -> F-CH2CO-S-CoA + AMP + PPi

The toxic effects of fluroacetate was studied in an experiment using intact rat heart.  After the heart was perfused with 0.20 mM fluoroacetate, the measured rate of glucose uptake and glycolysis decreased and Glu-6-P and Fruc-6-P accumulated.  The TCA components revealed that they were below normal except for citrate which was 10 times higher than normal.

Required:

Question 1: Where did the block in the TCA cycle occur?

Question 2: In the heart perfusion, why did the glucose uptake and glycolysis decrease and why the phosphorylated hexoses accumulate?

Reference no: EM132439749

Questions Cloud

Suspension of mitochondria in test tube : Buffer has excess of ADP, Pi, and pyruvate. Why would ATP production decrease after the addition of this molecule?
Electron transport chain complexes : What mechanisms do each of the electron transport chain complexes below use to pump/not pump protons?
Reflect on viewing the film ?Geralds Game? : Reflect on viewing the film Geralds Game? and the different ways which the film is similar to, or different from, a Stephen King book or movie
Delta g of atp hydrolysis : What effect would Mg2+ have on the delta G of ATP hydrolysis? (I think this question is related to glycolysis and the Mg2+-ATP coenzyme function).
Where did the block in the tca cycle occur : Where did the block in the TCA cycle occur? In the heart perfusion, why did the glucose uptake and glycolysis decrease and why the phosphorylated hexoses
How public health intervention plan for environment health : From Arab News (2014), Riyadh was ranked one of the most polluted cities globally according to UN. How can air pollution in Riyadh be resolved by public health.
Explain how it could affect evolutionary choice of dna : Explain how it could affect evolutionary choice of DNA as hereditary material.
What factors disrupt a teams ability to solve problems : How do the characteristics of the problem, team, and environment affect the way a team analyzes a problem?What factors disrupt a team's ability to solve problem
Side chain of the amino acid leucine : Why would Leucine would be in the interior, and serine would be on the exterior of the globular protein if the R- group, or side chain of the amino acid serine

Reviews

Write a Review

Biology Questions & Answers

  Which outcomes are not possible

Feather color in budgies is determined by two different genes, Y and B, one for pigment on the outside and one for the inside of the feather. YYBB, YyBB, or YYBb is green; yyBB or yyBb is blue; YYbb or Yybb is yellow; and yybb is white. A blue bud..

  Inventory management from perspective of software

Please respond to Questions 1 - 11 on page 87 in Word formatting. Ensure that you use APA formatting and cite outside sources including our text. Finally, in 300 words or more, discuss the trends in inventory management from the perspective of a s..

  Fatty acid from absorption to delivery to a cell

Compare the path of an amino acid to that of a large fatty acid from absorption to delivery to a cell.

  Autosomal dominant and autosomal recessive inheritance

Give an example of each. List and describe four structural changes that can take place in chromosomes.

  List physical factors that influence bacterial cell growth

List at least two physical factors that influence bacterial cell growth. Briefly describe how bacterial growth responds to changes in those factors

  Research how a organ transplantation is used today briefly

provide the referencesresearch how a organ transplantation is used today.briefly describe this biotechnology

  Discuss in detail how this will affect the heart and lungs

Now consider what happens if Jake starts smoking. Discuss in detail how this will affect the heart and lungs. Think about how this habit might affect the homeostasis of the cardiovascular and respiratory system.

  Prescribe an expectorant or suppressant

When treating pneumonia and/or bronchitis, would you prescribe an expectorant or suppressant? Please explain your rationale.

  Determine the phenotypic ratio of the offspring

Two plants in a cross were each heterozygous for two gene pairs whose loci are linked and twenty-five mu apart. Assuming that crossing over occurs during formation of both male and female gametes

  What is event that creates the absolute refractory period

What is the event that creates the absolute refractory period? a.Potassium leak channels close b.Calcium voltage-channels close

  Focus lot on the organ systems

Though we focus a lot on the organ systems, is it important to know the types and functions of the different cells and tissues also? Or in career in healthcare.

  Explain the cellular oxidation

How many molecules of ATP is generated via cellular oxidation by a hexanoic molecule, a glucose molecule

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

Submit Assignment

Academics

Major Subjects

Majors

Get In Touch

whatsapp: +1-415-670-9521

Phone: +1-415-670-9521

Email: [email protected]

TERMS & POLICIES

HELP & SUPPORT

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd