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What would be the consequence of tnf-alpha production

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Question - To determine which Mtb PAMPs could be recognized by NOD2, they added MDP (muramyl-di-peptide) and mAGP (mycoarabinogalactan peptidoglycan), an Mtb specific motif of PG, to their cells and measured TNF-alpha production as a downstream output confirming recognition.

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a. Which PAMP being recognized by NOD2 is required for Mtb-dependent TNF-alpha production?

b. In general terms, what would be the consequence of TNF-alpha production?

Reference no: EM131701494

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