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1. What Specific Aspects of Protein Biology Interest You?
2. Consider the relationship between DNA sequence and protein structure. To what extent is protein conformation genetically determined? To what extent is protein function genetically determined? What does this suggest about protein evolution (or evolution in general)?
3. Keeping in mind your response to question 2, consider that protein engineering, as a field, is still in its infancy. In your opinion, what are the challenges of synthesizing "designer proteins"? Provide a successful example from the literature, and briefly explain why it was able to work. This is an intentionally broad question, and could include anything from gene therapy to phosphomemetics used in research.
4. Pick two of the structures listen in Figure 2.12 and describe some of the structural motifs that you can identify in each of them. Note: I would suggest using CN3D or some other structure viewing software in order to make this a more meaningful exercise. You can highlight the primary amino acid sequence to highlight their location inside the protein.
b. Each structure in the figure has its name and a 4 digit protein bank identifier (PBID) shown in brackets. (e.g. Fig 2.12a is Uteroglobin[1utg]) You can easily find this structure by typing ‘1utg' into the NCBI structure database:
Assume if you were working with an organism like Arabidopsis, Drosophila, or any diploid organism that requires to use sexual reproduction to produce offspring.
The mutated form of hemoglobin in sickle-cell anemia results from the replacement of a glutamate residue by a valine residue at position 6 in the chain of the protein.
q1. you are conducting fieldwork and find out two groups of squirrels living on opposite sides of a lake. how would you
If the alleles of the pea color gene (Y,y) and the pea shape gene (R,r) did not assort independently and instead the alleles inherited from a parent always stayed together as a unit?
what is the order ofthe locion the chromosome.
Draft Research Questions
Barry Snowden, owner of Barry's Snowboards, would like to develop a page that would explain a list of snowboard types along with their descriptions.
If you were asked to create a karyotype from the chromosome spreads you made from HeLa cells in Activity 4.2.1, list materials you would use and explain how you would make the karyotype.
A persons normal tidal volume is 400 mL with a dead space of 100 mL. The respiratory rate is 12 breaths/min. The person is placed on ventilator for surgery and the tidal volume is 700 with a rate of 12. What is the approximate alveolar PCO2 for th..
Determine what effect did the agricultural revolution have on the growth of the human population?
Describe and diagram the synthesis of a secretory protein on membrane-bound, Er-localized ribosomes.
How have population and evolutionary genetics theory been used to detect signatures of recent natural selection in sequenced genomes, such as in human genomes.
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