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Problem
Consider the following Pharmacokinetic/Toxicokinetic information on 3 compounds in early testing at ACME Pharma (oral administration of 50mg/kg):
Drug
AUC (ng.h/mL)
Cmax (ng/mL)
Tmax (h)
t1/2 (h)
ACM-346
2200
189
1
5.6
ACM-369
848
71
4
2.5
ACM-410
7642
267
6
17
These drugs are being tested for hypotensive effects. Mechanistically, this is a peripheral effect - the target is a receptor on arteries.
The pharmacology team plans to test these compounds for desired activity. The animals' baseline blood pressure is tested then they receive single oral doses of test article and then at some period post dosing blood pressure is measured again. The typical design calls for measuring blood pressure 2 hours post dose.
Task: What recommendation would you make to your pharmacology team regarding the best time to measure PD effects for each of the compounds.
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