Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Huntington's disease is a rare autosomal dominant trait (lethal in the homozygous dominant condition). The mutation is an expansion of a nucleotide repeat in the DNA that encodes the huntingtin protein. Normal individuals have between 6-35 copies of a CAG repeat within the gene. Affected individuals can have between 36-121 repeats. In addition, as the number of repeated triplets (CAG) increases, the age of onset in the patient decreases. Individuals with this disease suffer from progressive neurodegeneration eventually resulting in death.
a. A 20-year old single woman whose father died of Huntington's disease is concerned about her risk of eventually developing the disease. What is the probability that she will eventually get HD, if her mother is phenotypically normal?
b. The HD gene has been sequenced and its location on chromosome 4 has been well characterized. The entire DNA sequence of chromosome 4 has been sequenced. A genetic screen can definitively determine whether this woman has the HD mutant allele.
i. What reaction components would be needed to PCR amplify the HD alleles from her genome?
ii. Once the alleles were amplified, how could you compare the size of her alleles to alleles from other individuals?
iii. If this woman was heterozygous at the HD locus, describe the sizes of the two PCR-amplified alleles and how they would compare to amplified alleles from both of her parents.
Explain homeostasis and briefly describe how each body system contributes to body-wide homeostasis. Finally, which two body systems contribute the most to homeostasis?
What are five major types of symbiosis associated with angiosperms, going back to the start of the eukaryotic line?
You are studying the expression of a proto-oncogene in a cancer cell and comparing it to expression in a non-cancer cell. You have done experiments to detect the presence of the proto-oncogene
The symptom of numbness of the palmar region often associated with carpal tunnel syndrome is caused by: Compression of the long extensor muscles of the hand. Compartmentalization of flexor and extensor muscles.
Cyanide binds to complex IV of the electron transport system, preventing the reduction of oxygen to water. Explain the ultimate effects of cyanide on electron transport, oxygen consumption, and ATP production. How can these in turn affect a person.
In a study of intraspecific aggression, an experimenter finds that sixteen out of 23 animals tested in species A exhibit aggression,
A section of the E. coli genome that encodes the pheM protein. Write out and label: the reverse complement, the mRNA sequence.
Myosin action differs from that of kinesin in that one of the kinesin heads is always in contact with a microtubule, whereas both myosin heads become completely detached from the actin filament.
Ti make toluidine blue stock solution, you add 1 gram of tolonium chloride to 100mL of 70% alcohol. In order to utilize this stain, you add 5mL of the stock solution to 45mL of 1% NaCl solution.
How would you expect the allocation of energy among plant organs to change as the amount of terrestrial ecosystem NPP increased? Explain why you would expect the allocation pattern you describe.
Phenylketonuria is an autosomal recessive genetic disorder. The frequency of homozygotes with this disorder is 0.0001. Determine the allele frequency for the dominant allele?
Turgor pressure builds up in a plant cell placed in a hypotonic environment. Why doesn't the plant cell burst like a red blood cell would?
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +1-415-670-9521
Phone: +1-415-670-9521
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd