What kind of mutations in lin-12 would cause

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The Notch signaling pathway functions in C. elegans vulval development. In a loss of function mutation of lin-12 Notch receptor none of the vulval precursor cells adopt 2° fate. Gain of function of lin-12 results in all vulval precursor cells adopting 2° fate. What kind of mutations in lin-12 would cause each of these phenotypes?

Reference no: EM13147777

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