What is Watson-Crick Model

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Reference no: EM133201253 , Length: 4 Pages

1. What is the Watson-Crick Model? Explain the importance of this while describing the details of the 3-D structure of DNA.

2. Explain what "chemical polarity" means in a DNA strand.

3. Describe in detail the tertiary structure of DNA?

4. What property of DNA allows the TATA box-binding protein to recognize the DNA helix?

Use the University of Florida Health Science Center e-journals to locate the following journal article (Use this article to answer the questions 5-7)

Goodsell D, Kopka M, Cascio D, and Dickerson R. (1993) Proceedings of the National Academy of Sciences of the United States of America, 90(7): 2930-2934.

Crystal Structure of CATGGCCATG and Its Implications for A-Tract Bending Models

5. What are the two distinct classes of bends in DNA double helices, and what are their characteristics

6. To what can the central bend in the CATGGCCATG decamer be attributed?

7. Is this bend considered to be intrinsic or induced? Explain.

8. What role do histones play in nucleosomes?

9. How are nucleosomes arranged in condensed fibers?

10. Describe the general organization of a eukaryotic chromosome.

11. Provide two examples of covalent modifications that can occur to the amino acid side chaise of the four histones in the nucleosome core. Are these types of modifications reversible?

12. Why would a researcher compare the DNA sequences of a human to a mouse?

13. Briefly explain how DNA footprinting works.

14. Describe how molecules of DNA can have different electrophoretic mobility

15. Compare the enzymatic machinery and mechanism of DNA replication in prokaryotes to that in eukaryotes

16. Discuss how viral DNA genomes replicate in the eukaryotic cell. In your discussion include three of the different viral replication mechanisms.

Reference no: EM133201253

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