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Question: Investigators enrolled 1000 COVID19 naïve individuals in a prospective cohort (follow-up) study. Subjects were examined once a year at the same time each year. The results of the first 3 years were as follows:
• Year 1: 0 cases of COVID detected; 6 lost to follow-up
• Year 2: 20 new cases of COVID detected; 20 more had died from other causes; 80 more lost to follow-up
• Year 3: 40 new cases of COVID detected; 20 more had died from other causes; 100 more lost to follow-up
NB: Loss to follow-up, died, and disease during year counted as 0.5 person years.
What is the total person-time incidence rate of COVID at year 3 in this study?
What factors would you examine to understand why some people developed COVID in this cohort?
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