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What is the seuqence of the anti-sense siRNA strand

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Question - Recent advances in molecular biology have resulted in a new therapeutic process called RNA interference (RNAi). The purpose of RNAi is to silence the expression of unwanted genes by targeting the destruction of the mRNA transcript. Small interfering RNA (siRNA) are short pieces of double-stranded RNA engineered by a scientist. Inside the cell, the double-stranded siRNA unwinds, the anti-sense siRNA strand complimentarily binds to the mRNA of interest, which is then headed for mRNA degradation. As a result, protein is not translated and expressed. In treating colorectal cancer you are interested in silencing the expression of a mutated gene called APC. The template strand of the APC gene is 3'-ATTGCGTAG-5'. For your RNAi experiment, what is the seuqence of the anti-sense siRNA strand needed to silence APC expression?

Reference no: EM131706617

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