Reference no: EM13496111
Question 1
In a small clinical trial. 10 patients with chronic pain were randomly assigned to receive either drug A or drug B for one month. After completing the month, they then had a two-week "wash-out" period during which no drug was taken, and then received the alternate drug for one month. At the end of the study, they were asked to state which drug they preferred because it gave them greater relief from the pain. Each patient had to choose one drug. Eight patients said that they preferred drug A.
(a) If drug A and drug B were truly equal in their effects in reducing pain, what would be the probability that a patient expressed a preference for drug A over drug B.
(b) How many ways are there of obtaining 10 patients expressing a preference for drug A. Repeat for 9 patients. 8 patients. ... 1, 0 patients. Tabulate your results.
(c) What is the probability of having eight patients express a preference for drug A if drugs A and B were truly equal in their effects? What is the probability of having eight or more patients express a preference for drug A under the same condition? Show how these probabilities can be obtained from your table in part (b).
(d) Draw your conclusions with regard to the finding that eight patients preferred drug A. Give the assumptions you have made in carrying out the above calculations and discuss their appropriateness
Question 2
When testing subjects for HIV in surveillance studies WHO protocol states that subjects whose test result is negative on the first test should be classified as 'HIV negative'. Subjects whose test result is positive on a first test should be retested twice and classified as 'HIV positive' if one or both of these retests are positive. If both of the retests are negative then the subject is classified as 'HIV negative'.
Let the sensitivity of a single test be x and the specificity be y. Write down, in terms of x and y the sensitivity and specificity of the tests carried out under the WHO protocol. Use these expressions to compare the effects of using the WHO protocol as opposed to using a single test. Discuss some of the advantages and disadvantages of the WHO protocol versus the single test. Give the assumptions that you have made in carrying out calculations.
|
Compute the magnitude of average drag force exerted on car
: A 82.7 kN car is travelling at 57.7 mph when the driver decides to exit the freeway by going up a ramp. computeb the magnitude of the average drag force exerted on the car
|
|
Position distributed with parameter lambda
: X is said to be Position distributed with parameter lambda >0 if it has the following pmf: PX(x)= (lambda ^x)*e^(-lambda)/ x! where x = 0, 1, 2... and 0 otherwise.
|
|
Explain sulfate was heated carefully until it had changed
: a 0.755 g sample of hydrated copper (II) sulfate was heated carefully until it had changed completely to anyhydous copper(II) sulfate (CuSO4) with a mass of 0.438 g. Determine the value of x
|
|
Identifying current assets and liabilities
: Dunn Sporting Goods sells athletic clothing and footwear to retail customers. Dunn's accountant indicates that the firm's operating cycle averages six months. At December 31, 2011, Dunn has the following assets and liabilities.
|
|
What is the probability of having eight patients
: How many ways are there of obtaining 10 patients expressing a preference for drug A. Repeat for 9 patients. 8 patients. ... 1, 0 patients. Tabulate your results.
|
|
How far is the submarine from the side of the ship
: a laser positioned on a ship is used to communicate with a small two man research submarine resting on the bottom of a lake. How far is the submarine from the side of the ship
|
|
Explain the original value at the same temperature
: At 50 degrees celsius a sample of ammonia gas exerts a pressure of 6.5 atm. What is the pressure when the volume of the gas is reduced to 20% of the original value at the same temperature
|
|
Discrete random variable with probability mass function
: Suppose that X is a discrete random variable with probability mass function: PX(x)= (1/2)^((2x/ pi)+1) , where x =0, pi/2, pi, 3pi/2, 2pi... , and equals to 0 otherwise.
|
|
Explain what is the pressure when the volume of the gas
: At 50 degrees celsius a sample of ammonia gas exerts a pressure of 6.5 atm. What is the pressure when the volume of the gas is reduced to 20% of the original value at the same temperature
|