What is the primary cause of the toxicities

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Reference no: EM133811926

Problem

A 55-year-old man who has had ulcerative colitis and has been on infliximab for 2 years with good control now presents with increasing fatigue, 15-pound weight loss, and an Hgb of 7 over a 2 month time span. Colonoscopy identifies a bleeding mass in the ascending colon, and biopsy specimens reveal well-differentiated colorectal cancer (CRC). He undergoes surgical resection and is found to have high-risk stage III CRC with metastasis to the lymph nodes. After surgery, he feels entirely well with no symptoms. Of note, he has no other comorbid illnesses. The patient receives a combination of 5-fluorouracil (5-FU), leucovorin, and oxaliplatin as adjuvant therapy. Get the instant assignment help. As he is leaving clinic and gets in the cold air, he feels like he cannot breathe. What is causing this to happen? CELINE About 5 days after receiving the first cycle of therapy, he experiences significant toxicity in the form of myelosuppression, severe diarrhea (approx. 3 liters a day), and pain in the hands and feet. What is the primary cause of these toxicities and how would you treat him, should any workup be done before the next cycle?

Reference no: EM133811926

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