What is the mechanism of this genetic disorder

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Assignment:

Jim was a normal, full-term baby at birth. Beginning at about 10 months of age, Jim started to get sick quite often from a series of infections such as rhinitis, bronchitis, sinusitis, and even serious illnesses as otitis media, pneumonia, and even sepsis. These conditions were successfully treated with antibiotics, but within a few weeks of the resolution of one infection, another would occur.

At about four years of age, Jim's pediatrician notes that Jim lacks palatine tonsils and adenoids, although he has no history of tonsillectomy, or adenectomy. Questioning of Jim's parents indicates that the father has negative history to report on his side, whereas his mother reveals that she had two male relatives who died in infancy from infectious diseases. The physician orders laboratory tests, which reveal that the quantity of immunoglobulin in Jim's serum is about one-fifth of normal, and that there is a marked deficiency in the number of circulating B-lymphocytes in Jim's blood. Tests to determine the functional state of Jim's T-lymphocytes are all normal.

Jim's diagnosis is a genetic disorder called X-linked Agammaglobulinema. He begins a course of monthly IV injections of gamma globulin, which he will need to continue for the rest of his life to help his immunity and normal growth.

What is the mechanism of this genetic disorder?
Explain X-linked inheritance, and name other genetic diseases that are known to be X-linked.
Why do sons have different outcomes than daughters?
Jim was free of infections for the first few months of life. Why?
Why did Jim lack tonsils and adenoids?

Reference no: EM133341909

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