What is the glomerular ?ltration rate

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Reference no: EM133640524

Assignment:

250 words for the whole set.

1) Given the following data:

Plasma concentration of PAH = 5 mg/100 ml
Urine concentration of PAH = 14.6 mg/ml
Urine flow rate = 2.4 ml/min
PAH extraction ratio = 0.9
Hematocrit ratio = 0.55

Calculate:

1A) Effective renal plasma flow

1B) True renal blood flow

(Hint: only about 90% of PAH is secreted through the tubules, so RPF X 90% = ERPF or RPF= ERPF/0.9)

(Remember RBF = RPF / 1- hematocrit)

2) Inulin was infused into the bloodstream of a 70 kg twenty year old male. During the infusion the urine flow rate was 2.4 ml/min, the arterial plasma concentration of inulin was 0.34 mg/ml, and the urinary concentration of inulin was 13.0 mg/ml.

2A) What is the glomerular ?ltration rate?

2B) How would you interpret this value?

3) Hypernatremia is an electrolyte disorder that causes a rise in serum or plasma sodium concentrations. Consider the implications of free water clearance and address the following:

3A) Identify and describe the body's two main defense mechanisms against hypernatremia.

3B) Explain how sodium contributes to tonicity and the movement of water.

Reference no: EM133640524

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