What is the function of peptide in neutrophils

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Q1: Type VI secretion systems (T6SS) are a complex biological machine in gram-negative bacteria.

a. Using Yersinia as an example system, describe the overall machine, name and describe the role of each protein in the T6SS (there are at least 13 proteins).
b. What is the function of the T6SS in Yersinia?
c. How many membranes does this system cross and what is the target membrane?
d. What is the energy used to "contract" the T6SS? Describe the cycle of Assembly, Extended form, Contraction and disassembly.
e. Describe the mechanism of effector translocation, and give an example of an effector that is transported in Yersina pestis. What is the function of this effector?
f. The Type VI secretion system (T6SS) in Vibrio vulnificus can perform a relatively unique function compared to the Yersinia T6SS. Describe the unique aspects of Vibrio vulnificus T6SS as compared to the Yersinia T6SS.
g. TheType VI secretion system (T6SS) in Francisellatularensis can perform a relatively unique function compared to the Yersinia T6SS. Describe the unique aspects of Francisellatularensis T6SS as compared to the Yersinia T6SS.

Q2: Antimicrobial peptides are part of the human innate immune system.
a. Describe the properties of the human cathelicidin antimicrobial peptide. How many genes are there for this peptide in human? Where is it expressed at high levels? What is the function of this peptide in neutrophils?
b. Describe the properties of the human alpha-defensin antimicrobial peptides. How many genes are there in humans for this class of alpha-defensin peptide? What are their functions and in what cells/part of the body are they highly expressed?

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Reference no: EM132880641

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