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Question- Pravastatin is a cholesterol lowering drug whose mechanism of action is the inhibition of HMG-CoA reductase. If a patient takes a 40.0 mg dose of pravastatin what is the concentration of pravastatin in the blood? Assume the patient has 5.0 L of blood. The molecular weight of pravastatin is 425.
Pravastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 2.3 × 10-3 ?M. What fraction of the enzyme will have a bound substrate under the conditions described above? Assume the concentration of HMG-CoA is 15 ?M, and the KM for HMG-CoA reductase is 1.4 ?M.
After a period of time, all but 0.10% of the pravastatin in the blood is metabolized. What fraction of the enzyme will have bound substrate under these conditions?
Your answer must be supported by illustrations, Please answer with work shown to receive points
This question about comparing elimination reaction of alkene with sodium methoxide and potassium tert-butoxide compare the results of the two E2 reactions you ran and discuss how using different bases affects the product composition
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How would the value of the atomic mass of the metal calculated be affected if the hot metal sample cooled off before it was transferred to the water in the calorimeter. would it be too high or too low
A solution of h2so4 with a molal concentration of 6.80 has a density of 1.318 g/ml. What is the molar concentration
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The recommended daily allowance (RDA) of calcium is 1200 mg. Calcium carbonate contains 12% calcium by mass. How many grams of calcium carbonate are needed to provide the RDA of calcium
A cylinder with a moveable piston contains 0.90 mol of gas and has a volume of 342 mL. What will its volume be if an additional 0.22 of gas is added to the cylinder?
Problem- Decide whether or not each of the following metals dissolves in 1 M HCl. For these metals that do dissolve, write a balanced redox reaction showing what happens when the metal dissolves.
calculate the molar mass of an unknown gas if 0.192 grams of the gas occupies a volume of 293 ml at 754.7 mm Hg and 22.5 degrees celsius.
complete and balance the equations for each of the following reactions: a)KHCO3(s)+HBr(aq)> b)Ca(s)+H2SO4(aq)> c)H2SO4(aq)+Ca(OH)2(s)> d)Na2CO3(s)+H2SO4(aq)>
If solar radiation is 1200 W/m^2, how many photons strike the leaf every second? Assume three significant figures and an average wavelength of 504 nm for solar radiation.
How many mL of 1.74 M HCl solution can react with 71.5 g calcium carbonate? CaCO3(s) + 2 HCl(aq) ? CaCl2(aq) + H2O(l) + CO2(g)?
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