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You have an appreciation for the complexity of protein structure. As many of you have indicated in your problem set responses, knowledge of DNA sequence can only take us so far. Genomics may have given rise to proteomics, but the two fields really are evolving in parallel as this point. As you probably appreciate from your reading and from exploring the three dimensional protein structures using CN3D, protein biophysics can be very complex. However, there is also an important role for "unfolded" proteins in physiology and disease.
1. Given that protein folding is largely determined by primary structure, what is the role of chaperone proteins? Bukau et al discuss the role of some of the major players, like HSPs, in proper protein folding.
2. Is it beneficial that some proteins do not generate higher order structures? De Simone et al discuss the role and properties of Intrinsically Disordered Protein Regions (IPDs), what is the take home message?
3. What is the role of misfolded proteins in disease? To come full circle, how does protein misfolding fit into our "protein evolution" model? I am offering two perspectives as a starting point for this discussion.
It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.
This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.
Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.
This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.
Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?
Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.
Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.
The use of PCR and genetic approaches in biotechnology
Glucose oxidase is an enzyme that can be used for measurements of glucose levels by combining this reaction with an oxygen probe.
What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?
Prepare an essay on nosocomial infection.
To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.
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