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You have an appreciation for the complexity of protein structure. As many of you have indicated in your problem set responses, knowledge of DNA sequence can only take us so far. Genomics may have given rise to proteomics, but the two fields really are evolving in parallel as this point. As you probably appreciate from your reading and from exploring the three dimensional protein structures using CN3D, protein biophysics can be very complex. However, there is also an important role for "unfolded" proteins in physiology and disease.
1. Given that protein folding is largely determined by primary structure, what is the role of chaperone proteins? Bukau et al discuss the role of some of the major players, like HSPs, in proper protein folding.
2. Is it beneficial that some proteins do not generate higher order structures? De Simone et al discuss the role and properties of Intrinsically Disordered Protein Regions (IPDs), what is the take home message?
3. What is the role of misfolded proteins in disease? To come full circle, how does protein misfolding fit into our "protein evolution" model? I am offering two perspectives as a starting point for this discussion.
Compare the effects of the destruction of the spinal nerves dorsal root ganglion and the destruction of the ventral roots.
During the normalcardiac cycle, the arteria contract when they are directly stimulated by:
The seeds of orchids are among the smallest known, with virtually no endosperm and with miniscule seed leaves. As a result, what must one expect to be true of such seeds.
In guinea pigs, black coat is dominant to albino, so that true breeding lines of black animals, crossed to albino animals,yield an F1, that is all black.
What factors are important in structuring the community and determining the number of species and the absolute and relative abundance of each species in the community?
Determine concentrations of diluted samples then use that information to calculate the protein concentration of the original milk Can someone please explain what i have to do PLEASE
Drosophilafemales homozygous for the third chromosomal genes pink-eye and ebony body were crossed with males homozygous for 2nd chromosomal gene apterous wings.
In another population of butterflies, you do a survey and find that out of 5000 individuals you examine, only 4 had curly antennae. What would you expect the frequency of heterozygotes to be in this population? What about the frequency of homozygo..
Describe how the body axes of the bird are determined. Describe how the bird embryo blastulates.
When Tammy Byrd first entered a dark room she could not see well. In fact, she was momentarily blind. With time, however, her vision improved and was able to discern her surroundings. Explain this physiological phenomenon in terms of a light adapt..
Contrast constitutive genes from inducible genes. Give two examples for each.
A hypothetical grassland system contains two species of grass, two species of rodent that eat grass, and one species of snake that feeds on the rodents.
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