What is probable mechanism of renal clearance for drug

Reference no: EM133688309

Question

A single 250-mg oral dose of an antibiotic (20% bound to plasma proteins) is given to a female patient (age 32 year, 5'6'', SCr = 1.1 mg/dL, 74 kg). From the literature, drug is known to have an apparent Vd equal to 21% of body weight and an elimination half-life of 2 h. The dose is 90% bioavailable. Urinary excretion of the unchanged drug is equal to 158 mg. Please show your work.

1. What is the creatinine clearance (mL/min) of this patient? Is the patient clinically obese?

2. What is the total body clearance for this drug? (both in L/h and mL/min)

3. What is the renal clearance for this drug (both in L/h and mL/min)

4. What is the probable mechanism of renal clearance for this drug?

Reference no: EM133688309

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