What is it about the genogram for the ke family

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Question: Several years before scientists were able to do the genetic testing on the KE family that revealed the role of the FOXP2 gene and its mutation, they were able to demonstrate that it was very likely that the disorder was genetic in nature. The main evidence for this supposition was that the distribution of the disorder across generations followed a typical pattern for autosomal dominant inheritance.

This is interesting because in principle it is possible for a single large family to have an unusual (even remarkably) a large number of individuals within it who have some specific rare disorder without that pattern reflecting any sort of genetic issue. The pattern might arise purely by chance or as an effect of some environmental toxin present someplace where many members of the family would be exposed to it. There are also other kinds of inheritance patterns (such as the autosomal recessive example we have used) that might, with the addition of further evidence, suggest a genetic factor.

So, what specifically led the scientists to strongly suspect a genetic cause for the disorder in the KE family? Refer to the comparison between the KE family genogram and the others. What is it about the genogram for the KE family that makes it more similar to the autosomal dominant example than it is to any of the other patterns evident in the other four genograms?

Reference no: EM133321675

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