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As humoral responses progress, the average affinity of the antibodies produced rises, in a process known as "affinity maturation." This seems at odds with at least one aspect of the clonal selection hypothesis, since the notion of "clonal integrity" implies that the progeny of an activated lymphocyte retain the specificity the original, pre-immune, antigen receptor. So here are the questions:
What is the basis for "affinity maturation" in humoral responses?
Does this contradict the tenets of clonal selection? Perhaps a bit more broadly, does this force rejection of the clonal selection hypothesis as a viable model to explain the cellular basis for specificity of adaptive immunity?
At the end of the response, you should raise an issue you are curious about related to the topic in the question.
It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.
This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.
Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.
This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.
Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?
Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.
Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.
The use of PCR and genetic approaches in biotechnology
Glucose oxidase is an enzyme that can be used for measurements of glucose levels by combining this reaction with an oxygen probe.
What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?
Prepare an essay on nosocomial infection.
To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.
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