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Questions:
1. What features of the study support investigators' claim that they used a nested case-control design?
2. How many cases and how many controls were used for the primary analyses? When answering this question provide data separately for each of the two study cohorts.
3. To what extent are you satisfied exposure preceded the study outcome?
4. Did the matching criteria limit the number of cases who could be included in analyses? Provide a brief justification for your answer.
5. To what extent might study conclusions have been affected by selection bias? Provide a brief justification for your answer.
6. To what extent might study conclusions have been affected by information bias? Provide a brief justification for your answer.
Article
Filion KB, Azoulay L, Platt RW, et al. A multicenter observational study of incretin-based drugs and heart failure. New England Journal of Medicine 2016; 374: 1145-1154.
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