What defect is associated with this oncogenic mutation

Reference no: EM13527105

In the signal transduction lecture, we established that the BCR-ABL translocation creates a membrane bound receptor with constitutive kinase activity. What defect is associated with this oncogenic mutation?

A. An increase in phosphorylation of the substrate (compared to wild type)
B. A defect that attenuates signaling from the BCR-ABL kinase
C. A failure of the BCR-ABL fusion gene to localize to the plasma membrane
D. A decrease in phosphorylation of the substrate (compared to wild type)
E. Apoptosis

Reference no: EM13527105

Questions Cloud

Extracellular concentration-calculate the chemical potential : Suppose that the extracellular concentration of Cl– is 123 mM and the intracellular concentrationis 4 mM. The membrane electrical potential (?V) is 0.06 V, inside negative relative to outside.

Generator and degradations - acquisition : Plot the autocorrelation function and show that other than peak there are only three values in the autocorrelation. What are the values of the autocorrelation function?

Explain the predominant isotope of gold : The predominant isotope of gold, , has an experimentally determined exact mass of 196.967 . What is the total nuclear binding energy of gold in electronvolts per atom

Explain the cylinder if the volume was changed : More helium was added to the cylinder and the volume was adjusted so that the gas pressure remained the same. How many grams of helium were added to the cylinder if the volume was changed from 2.00 \rm L to 3.30 L

What defect is associated with this oncogenic mutation : In the signal transduction lecture, we established that the BCR-ABL translocation creates a membrane bound receptor with constitutive kinase activity. What defect is associated with this oncogenic mutation?

Find the total energy stored in the network : Two capacitors are in a series. C1=150nF and C2=120nF. The potential difference across them is 36 volts. Find the total energy stored in the network

Response to epinephrine to stimulate glycogen breakdown : The response to epinephrine to stimulate glycogen breakdown involves which of the following steps?

Find how high does cheese rise from this initial position : A piece of cheese with a mass of 1.11 kg is placed on a vertical spring of negligible mass and a force constant k= 2000N/m that is compressed by a distance of 17.9cm

Define the animal''s initial radiation exposure in curies : What is the animal's initial radiation exposure in Curies. If all of the energy from the emitted alpha particles is absorbed by the animal's tissues, and if the energy of each emission is 7.77*10-12

User Account

All Pages