What could be the underlying mechanism

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Question: Although transplantation of maternal bone marrow cells resulted in successful T-cell reconstitution, Martin remained unable to produce antibodies. This failure of B-cell reconstitution is often observed in patients with X-linked SCID or with JAK3 deficiency, even when the transplant is performed from an HLA-identical donor. What could be the underlying mechanism?

Reference no: EM133544678

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