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Problem
BRCA1 encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified
• Read through the summary. What cellular processes and/or functions is this gene involved in? For example, it is important for cell survival? Apoptosis? Microtubule formation?
Which of these lipids are amphiphilic? Explain why or why not based on their structures.
Transcranial magnetic stimulation (TMS) is a noninvasive technique used to stimulate regions of the human brain. A small coil is placed on the scalp, and a brief burst of current in the coil produces a rapidly changing magnetic field inside the br..
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Go to the Science Blogs Website and read the blog post titled "Dichloroacetate and cancer". Explain how the blog post ties in with this week's lessons
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If the mother is heterozygous for the trait and the father is homozygous dominant for the trait would their child be expected to have sickle cell anemia? Explain why or why not.
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