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Case Study: A 78-year-old man was diagnosed with non-Hodgkin's lymphoma 3 months previously. The patient has not yet begun to receive chemotherapy and staging studies suggest a localized disorder. The lab results are below. WBC: 10.3 x 10e9/L Hgb: 12.0 g/dL Hct: 33.1% MCV: 81 fL PLT: 221 x 10e9/L Peripheral blood smear: normocytic, hypochromic RBCs without significant anisocytosis or poikilocytosis. A bone marrow biopsy was performed to rule out any involvement in the bone marrow by the malignant lymphoma. Examination of the bone marrow revealed no evidence of malignant lymphoma spread, and iron stains were performed.
Questions: 1-5 refer to Case #2 Given the lab results above and the presentation and history of the patient, what type of anemia does he most likely have? If serum iron studies were done on this patient what would be the results given the type of anemia he most likely has? (serum iron, serum ferritin, TIBC) If Prussian blue staining of a bone marrow examination was on this patient was performed, what would it reveal? What cell types would the staining be found in? What is the etiology (etiology=cause) of this disorder? Describe the role of hepcidin in this disorder. What cells are particularly affected
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