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a. Two arrestin genes (β -arrestin 1 and 2) have been characterized and are expressed ubiquitously. Over the past several years, the development of knockout mice in which the genes for β-arrestin 1 and 2 have been inactivated have greatly aided the study of the physiological and cellular roles of these multifunctional proteins.
To better understand the role of β-arrestin 1 and 2 in the desentitization of the β2 - R small interfering RNA (RNAi) were used to specifically suppress the expression of β arrestin 1 or 2 or both. The results are shown in the figure below.
What does this figure show in term of specificity of the two siRNA molecules (β-arr1 and β -arr2)?
b. The effect of the siRNA -mediated β-arrestin depletion on cAMP accumulation by endogenously expressed β-AR2. The cells were transfected with the indicated siRNA molecules and subsequently stimulated with isoproterenol (epinephrine).
As a control the cells were not stimulated with Isoproterenol (NS). Data are expressed as percent of agonist-induced cAMP accumulation in control RNA-treated cells. What β arrestin protein (1 or 2) participates in the desensitization of the β -AR2? Justify your answer.
It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.
This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.
Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.
This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.
Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?
Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.
Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.
The use of PCR and genetic approaches in biotechnology
Glucose oxidase is an enzyme that can be used for measurements of glucose levels by combining this reaction with an oxygen probe.
What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?
Prepare an essay on nosocomial infection.
To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.
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