What are the pathophysiologic and clinical differences

Reference no: EM133284590

Assignment - Pathophysiology Case Study

Description - You admitted Mr. Morgan, a 62-year-old male, who presented to the ED yesterday morning with hematemesis. The CT scan, MRI, and endoscopy confirmed he has bleeding esophageal varices. His wife was present and explained he was diagnosed with metabolic syndrome about three years ago which they tried to control with diet and exercise. However, last year he was diagnosed with Type 2 diabetes. He weighed 218 lbs., his BMI was 31, and his hemoglobin A1c was 7.8 which indicated Mr. Morgan was obese. Mr. Morgan was upset and concerned with his diagnosis, so he went on a very low-calorie diet (VLCD) eating only 800 calories a day. He lost 48 pounds quickly in 8 weeks. Mr. Morgan explained he was happy he lost the weight, but he was very tired and weak on the VLCD. When he started adding more calories he felt better but he gained back 20 lbs. He has not gained any more weight and had maintained his weight by exercising. His wife tells you about two months ago he started losing weight again but not from dieting. He stopped exercising because he says he is too tired. Mr. Morgan tells you he does not feel like eating because he is never hungry anymore. He said his stomach just feels full all the time.

You are assigned to care for Mr. Morgan the next day and when you enter his room you find Mrs. Morgan crying. She explains the doctor was in earlier and told them the doctor scheduled Mr. Morgan for a liver biopsy to rule out cirrhosis of the liver. Mr. and Mrs. Morgan tell you he does not drink alcohol now and he does not have a history of drinking alcohol. They are confused and ask you how can he have cirrhosis of the liver when he never drank alcohol.

After reviewing Mr. Morgan's medical history, lab results, radiology results, and the information Mr. & Mrs. Morgan have told you regarding his medical history, you recognize Mr. Morgan had nonalcoholic fatty liver disease (NAFLD) due to his obesity which then progressed to nonalcoholic steatohepatitis (NASH) which could result in cirrhosis of the liver.

Explain the pathophysiology of the advancement of Mr. Morgan's diseases.

Then discuss how you will explain this information to Mr. & Mrs. Morgan in terminology they will understand.

Did Mr. Morgan's rapid weight loss contribute to his disease? Why or why not?

What is the pathophysiologic reason Mr. Morgan does not feel hungry and feels full all the time?

Why did Mr. Morgan's advancement of his disease present as acute variceal bleeding in his esophagus? What is the etiology?

What are the pathophysiologic and clinical differences between nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)?

Reference no: EM133284590

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