What are the challenges in the field of glyco-biology

Assignment Help Biology

Reference no: EM133463373

Homework

Topic: Glycoproteins, glycosylation & Cancer

You learned about the importance of glycoproteins, glycosylation and the "sugar code" and its importance for many important cellular processes, ranging from cell-cell interaction, immune function and cancer. You heard that the extracellular carbohydrate coat, called glycocalyx, plays a role in tumor formation and progression. As you work on this homework, consider that approximately half of all human proteins known to date are glycosylated and the majority cancer biomarkers are comprised of glycoproteins. About 270,000 new cases of breast cancer are diagnosed in the U.S. per year and 6.9% of all cancer related deaths will result from breast cancer. Also consider that the human receptor tyrosine-protein kinase erbB-2 (HER2), one of the proteins found mutated in many breast cancer patients, has multiple sites of N-glycosylation important for its biological function.

Read the following scientific review article:

Scott D.A. & Drake R.R. Glycosylation and its implication in breast cancer. Exp. Rev. Proteomics. 2019 Aug.; 16(8): 665-680) and also do some additional literature research on NCBI PubMed on this topic.

Then discuss the following aspects with your class mates:

Question A. Is there scientific evidence showing a role of glycosylation in tumor development and/or metastasis?
Question B. Which enzymes important for glycosylation are discussed to play a role in tumorigenesis, particularly in breast cancer?
Question C. Which sugar residues and "glyco-antigens" are discussed to play a role in tumorigenesis, particularly in breast cancer?
Question D. What are the diagnostic methods used to detect alterations in glycosylation patterns amongst normal cell and tumor cells?
Question E. What is meant by the term "sugar code"?
Question F. What are the challenges in the field of glyco-biology?

Reference no: EM133463373

Questions Cloud

What you think is biggest nutrition-related health problem : What do you think is the biggest nutrition-related health problem facing the US? How can we change this? want to know what you all think too!

Analyze the potential effectiveness resulting : Analyze the potential effectiveness resulting from professional or nurse-provided social support versus enhancement of social support provided by personal

Provide me with at least five key events of the movement : Provide me with at least five key events of the Movement, the events that led up to those key events, and where the Movement succeeded and failed.

Describe one type of drug used to treat the type : Describe one type of drug used to treat the type of diabetes you selected, including proper preparation and administration of this drug. Be sure to include

What are the challenges in the field of glyco-biology : Is there scientific evidence showing a role of glycosylation in tumor development and/or metastasis? What are the challenges in the field of glyco-biology?

Explain one practical strategy : Explain at least one practical strategy, in detail, that you (or individuals) may be able to implement in daily life to improve either food availability.

Discuss major barriers to fpa in your state : Discuss major barriers to FPA in your state. Finally, discuss how you plan to be involved in your state's governance and/or advocacy for APRNs.

What details did the patient provide : What details did the patient provide regarding their chief complaint and symptomology to derive your differential diagnosis? What is the duration and severity

How can knowing what is in food you eat change what you eat : What about food without a nutrition label? Do you always know what is in your food? How can knowing what is in the food you eat change what you eat?

User Account

All Pages