What are mechanisms that cause these hematologic disorders

Reference no: EM133344549

Advanced Pathophysiology

Case Study: Disorders of Hepatobiliary and Exocrine Pancreas Function

Robert is a 68-year-old who has dealt with alcoholism for over 30 years. He has cirrhosis and is anemic. His appetite has declined, and he regularly complains of abdominal pain. Recently, while preparing himself a sandwich, he cut his finger deeply with a knife. The wound bled profusely, and he used a kitchen towel to stop the flow. Refusing to go and seek medical assistance, he put ice on his finger and wrapped the towel around it. He sat down in his recliner with his hand over his head and fell asleep.

Question 1. Anemia and clotting disorders are common features of alcoholic liver disease. What are the mechanisms that cause these hematologic disorders?

Question 2. What gastrointestinal bleed is associated with a high mortality rate in those with advanced cirrhosis? What is the pathophysiology of this condition?

Question 3. Acute pancreatitis is sometimes seen in alcoholics, particularly after binge drinking. Why are tachycardia and hypotension indications of this condition?

Question 4. Why are women more predisposed to alcoholic liver disease than men?

1. TEXTBOOK:
Norris, T.L., (2019). Porth's Pathophysiology: Concepts of Altered Health States (10th ed.). Wolters Kluwer
**Must use this textbook edition only and cite pages from this edition. **Include a description of the injury at the cellular level. Evaluate the presence and effects of alterations in the homeostatic state secondary to gender, genetic, ethnic, and temporal variables.

2. In addition to the text, three peer-reviewed articles that are relevant to the content and published within the last five years. **If Websites are used, they must be evidence-based and cited on a reference list per APA 7th edition format.

3. Reference list must be in APA 7th edition format. **In-text citations must include page numbers. **Please do NOT use "n.d" articles or sources.

4. 4 pages double spaced excluding reference list (Do not include the question in word count)

5. Thorough identification of the importance of the subject matter to the individual, clinical, and professional.
• Supports discussion concepts through evidence-based information.
• Clear critical thinking acknowledges application, analysis, synthesis, and evaluation.

6. No grammar, word usage, or punctuation errors.

Reference no: EM133344549

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