What additional change to primary protein structure

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In humans, PFKR is a protein that is secreted from cells. A team of scientists decide to redirect PFKR to the inside of the nucleus instead of having it secreted. The scientists change the primary protein sequence so that it is no longer secreted from the cell (it remains in the cytosol), but unfortunately, the modified protein does not enter the nucleus.

1. Describe what additional change(s) to the primary protein structure you would suggest to ensure that PFKR reaches the inside of the nucleus.

2. Describe the path PFKR, outlined in (A) above, would take to reach the inside of the nucleus. Start your description from the place in the cell where protein synthesis begins. Include all relevant cell regions and/or structures in your description.

Reference no: EM133261593

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