Wat are the acidic pka values of the respective hydroxyl

Assignment Help Chemistry
Reference no: EM13589050

Question 1)

Heroin is 3, 6-diacetylmorphine. Heroin is 2-3 times more potent than morphine.

In vitro and in vivo, to which product does heroin hydrolyze first, (3- or 6-acetylmorphine), and why?

Hint: What are the acidic pKa values of the respective hydroxyl products? Look up the structures on the internet or use the UF library online e-journals.

Question 2)

Acetylsulfisoxazole, is readily hydrolyzed in vivo to sulfisoxazole. On the other hand, the acyl group in amikacin, is stable to hydrolysis in vivo. Both acetylsulfisoxazole and amikacin are acyl derivatives where the acyl group is attached to nitrogen.

Why is one stable and the other not?

Hint: What are the acidic pKa values of the respective N-H groups formed on hydrolysis. Look up the structures on the internet or use the UF library online e-journals.

Reference no: EM13589050

Questions Cloud

Light illuminates two closely spaced thin slits and : question light illuminates two closely spaced thin slits and produces an interference pattern on a screen behind. how
The burst occurs 1500m above you and traveled vertically : question the sound from a very high burst of fireworks takes 4.5 seconds to arrive at your eardrums. the burst occurs
Working capital often increases as the result of higher : consider the following statements about the investment in working capital in a capital budgeting analysisi. working
Borderbooks company has two locations downtown and at a : borderbooks company has two locations downtown and at a suburban mall. during march the company reported net income of
Wat are the acidic pka values of the respective hydroxyl : question 1heroin is 3 6-diacetylmorphine. heroin is 2-3 times more potent than morphine.in vitro and in vivo to which
American food services inc acquired a packaging machine : american food services inc. acquired a packaging machine from barton and barton corporation. barton and barton
A company issued 10-year bonds with a par value of 20000000 : a company issued 10-year bonds with a par value of 20000000 and an 8 annual face on january 1 2014. the market rate on
Myriad solutions inc issued 10 bonds dated january 1 with a : myriad solutions inc. issued 10 bonds dated january 1 with a face amount of 320 million on january 1 2013 for
The bookkeeper of vitial inc has asked to assist him with : the bookkeeper of vitial inc has asked to assist him with preparation of financial information about the companys trade

Reviews

Write a Review

Chemistry Questions & Answers

  Steps in the mechanism for the following reaction

Show all the steps in the mechanism for the following reaction, When benzene is mixed with deuterated sulfuric acid, deuterium is slowly incorporated onto the ring. Show the mechanism for this reaction and explain how this relates the sulfonation of ..

  Prior to placing piece of metal into the graduated cylinder

This assignment inhibits chemistry Laboratory Questions.

  Write the structures of the saytzeff elimination

Write the structures of the saytzeff elimination

  Calculate ph - chemistry questions

Chemistry Questions on Calculate P H

  How many mols of hydrogen can produce

how many mols of H 2 can produce

  Analysis of corrosion mechanisms

Analysis of corrosion mechanisms and preventative measures

  Chemical and pharmaceutical science

Write an equation for the formation of an acetal from reaction of excess methanol with benzaldehyde in the presence of an acid catalyst.

  Calculate the approximate sulphur

Calculate the approximate SO 2 mass emission in lb/day.

  What is the structure - stereochemistry

What is the structure (including functional groups)? Stereochemistry (racemic or single enantiomer)?

  Design a qualitative analysis scheme

Design a qualitative analysis scheme

  What will be the resultant pressure

What will be the resultant pressure when the stopcock is opened?

  The 1h nmr spectrum

Integrals for some of the resonances in the 1H NMR spectrum are higher than they should be due to the shear number of hydrogens in this compound

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd