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Question 1)
Heroin is 3, 6-diacetylmorphine. Heroin is 2-3 times more potent than morphine.
In vitro and in vivo, to which product does heroin hydrolyze first, (3- or 6-acetylmorphine), and why?
Hint: What are the acidic pKa values of the respective hydroxyl products? Look up the structures on the internet or use the UF library online e-journals.
Question 2)
Acetylsulfisoxazole, is readily hydrolyzed in vivo to sulfisoxazole. On the other hand, the acyl group in amikacin, is stable to hydrolysis in vivo. Both acetylsulfisoxazole and amikacin are acyl derivatives where the acyl group is attached to nitrogen.
Why is one stable and the other not?
Hint: What are the acidic pKa values of the respective N-H groups formed on hydrolysis. Look up the structures on the internet or use the UF library online e-journals.
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Match the following properties of liquids to what they indicate about the relative strength of the intermolecular forces in that liquid. Strong intermolecular forces: Weak intermolecular forces
A gaseous mixture contains 420.0 Torr of H2(g), 391.3 Torr of N2(g), and 79.5 Torr of Ar(g). Calculate the mole fraction, X, of each of these gases.
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