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CH3403 Bio-imaging Applications of Coordination Chemistry
On completion of the module a student should be able to Knowledge• know the fundamental concepts and principles that underpin optical imaging, magnetic resonance imaging and radioimaging via SPECT and PET techniques.• understand the concepts that drive the ligand design and choice of metal ion for a given imaging application• know the synthetic pathways to the target species, and spectroscopic techniques required for elucidating the key physical properties of the imaging agents.• know the key methodologies for ensuring biocompatibility and complex stability in vitro and in vivo.
Understanding• understand how spectroscopic techniques can be used to underpin the design of imaging agents.• understand the pros and cons of different classes of metal complex species to a given imaging technique• appreciate the biological implications and restrictions associated with the different imaging modalities.
Show all the steps in the mechanism for the following reaction, When benzene is mixed with deuterated sulfuric acid, deuterium is slowly incorporated onto the ring. Show the mechanism for this reaction and explain how this relates the sulfonation of ..
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