Treatment with iv atovaquone and iv azithromycin

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After consultation with Bruce's urologist and with consideration of his already impaired renal function, treatment with IV atovaquone and IV azithromycin was begun. However, Bruce's condition continued to worsen and he died in the hospital within a month of his transplant.

Atovaquone is an analog of ubiquinone (coenzyme Q) and appears to bind to the mitochondrial cytochrome bc(1) complex. This blocks the transfer of electrons to cytochrome c in the electron transport system which depletes the parasite's cells of ATP. Based on the cellular target and mechanism of this drug, would atovaquone be a useful antibiotic to treat a bacterial infection?

Reference no: EM132685287

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