Transferring of t-lymphocytes in graft versus host disease

Reference no: EM1315004

Transfer of the immunologically competent T-lymphocytes from a donor into host expression different MHC antigens can have severe consequences, causing a fatal syndrome known as graft versus host disease (GVH). The following table explores a ran model of GVH, it displays the minimum number of parental strain t- cells which cause fatal GVH in sevearl treatment groups of F1 hybrid off spring derived from mating of two MHC different strain, a and b.

		Minimum number of A or B strain t- cells which cause lethal GVH in the AxB F1 10⁶
Group	(A X B) F1 hosts age and treatment	Strain A T cells	Strain B t cells
1	Intreated new born F1	5	5
2	Untreated adult f1	1000	1000
3	Adult F1 given 300 rad irradiation or an anti - proliferative drug	5	5
4	Adult F1 immunized with 10 of the strain parental t - cells and then irradiated as in group 3	1000	5
5	Adult F1 immunized with 107 a strain t- cells taken from donors that had previously been made tolerant to MHC of B, and then irradiated as in group 3.	5	5

Give a mechanistic explanation for finding which is consistent with all the data. Describe your answer with reasoning.

Reference no: EM1315004

Questions Cloud

The simple group of order : The simple group of order.

Computation of wacc for a firm : Computation of WACC for a firm and based on the information provided, calculate the weighted average cost of capital (WACC)

Questions based on stocks and debts : Multiple choice questions on stocks and debts - Which of the following statements is CORRECT?

How far to the right of where the string : 50 g ball travelling at 25.0 m/s is bounced off a brick wall and rebounds at 22.0m/s. A high-speed camera records this event. If the ball is in contact with the wall for 3.51 ms, what is the average acceleration of the ball throughout this time inter..

Transferring of t-lymphocytes in graft versus host disease : Transfer of the immunologically competent T-lymphocytes from a donor into host expression different MHC antigens can have severe consequences, causing a fatal syndrome known as graft versus host disease (GVH).

Assuming the industry is a cournot duopoly : Illustrate what will be the price of this new drink in the long run, assuming the industry is a Cournot duopoly.

Describing whether smoking is confounder : A case-control study of relationship between liver cirrhosis among both non alcoholics and alcoholics. Describe whether smoking is confounder.

Claiming using chi-square test : A student team examined parked cars in four different suburban shopping malls. One hundred vehicles were examined in each location. Research question: At α = . 05, does vehicle type vary by mall location?

What is the mass of the ball : A 71 kg skier encounters a dip in the snow's surface that has a circular cross section with a radius of curvature of 12 m. If the skier's speed at point A is 7.0m/s , what is the normal force exerted by the snow on the skier at point B? Ignore fricti..

User Account

All Pages