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Think about the normal physiological processes

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In many individuals with severe cases of A1AT deficiency (the ZZ genotype), intracellular accumulations in the liver are usually noted upon biopsy. What might be the cause of this phenomenon? What are the accumulations of, where in the cell would you expect to find them and why, and where do they come from? Hint... think about the normal physiological processes that occur within a cell, and how the defective A1AT protein arising from the Z allele might interfere with these processes.

Reference no: EM133360672

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