Therapeutic approach for solid tumors

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In CAR-T therapy, T cells are engineered so that they have high selectivity for tumor cells. From the list below, indicate which ones (if any) are current "challenges" in this therapeutic approach for solid tumors like carcinomas.

(i). The cost of engineering the DNA constructs and delivering them to the T cells in a targeted fashion.

(ii). Identifying tumor-associated or specific-antigens.

(iii). Isolating and culturing the patients' T cells.

(iv). Access of the engineered T cells to the tumor.

(v). Inducing cytokine storms.

Reference no: EM132548028

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