Terminating the action of g-protein coupled systems

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Think about these two facts: a) The alpha-subunit of the G-protein trimer has an intrinsic GTPase activity, which is important in terminating the action of G-protein coupled systems. b) The CFTR is activated by cAMP. Here’s the question: If you introduced a toxin into the intestinal cell that blocks the intrinsic GTPase activity of a stimulatory G-protein (Gs), what would be the most significant effect on intestinal function? Briefly explain the mechanism underlying your answer, including the most important steps in the signal transduction pathway.

Reference no: EM1382609

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