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The statement either:
- Supports a potential large-scale chromosomal translocation
- Supports a potential large-scale genomic deletion
- Supports a potential large-scale genomic insertion
Supports a potential point mutation in the genome
Suppose you sequence the genome of the healthy cells and the genome of tumor cells. You map the sequence reads of both healthy and tumor cells to the reference genome.
Indicate whether the statements below support a potential large-scale genomic deletion or insertion, large-scale chromosomal translocation, or a point mutation in the genome.
1. A single read from the tumor sample maps to the start of chromosome 8 and chromosome 21 of the reference genome.
2. A single read from the tumor sample shows a silent mutation compared to the human reference genome.
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