Summarize the in vivo and in vitro evidence suggesting

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In a normal pregnancy a progressive maternal plasma volume expansion (PVE) occurs, due to continual renal Na retention, which is important for optimal fetal development. However, this involves some major modifications in kidney function, because a normal, non-pregnant individual CANNOT undergo chronic PVE and renal Na retention. Furthermore, chronic PVE in non-pregnancy is associated with increases in blood pressure (BP) but in normal pregnancy, BP falls despite persistent PVE.

Briefly summarize the "in vivo" and "in vitro" evidence suggesting that the renal tubular responsiveness to NO and ANP is altered in normal pregnancy. ANSWER (about 400 to 500 words)

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Reference no: EM133276308

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