Reference no: EM133199525

Please answer this question after researching and the answer should be more than five hundred words for both. Please provide references. Thank you so much. I will be sure to upvote if you answer the question properly.

1 a) The strengths of immunotherapy are that it is durable and dynamic.  Explain what is meant by this.  In your answer, compare and contrast immunotherapy strategies with targeted therapies (e.g. tyrosine kinase inhibitors).  You should consider the target of the agent, the timing of when this agent may be given in the course of the disease, the likely duration of the response, and how would you evaluate the efficacy of these two agents.

b) The term "plasticity" has been used when describing several different concepts in cancer biology and the development of cancer therapeutics.  This term has been used in describing the concept of cancer stem cells, in the context of epigenetic alterations, and also applies to thinking about how cancer cell metabolism or interaction of cancer cells with immune cells changes over time.  Describe what "plasticity" means using at least two examples from the course. Include in your answer how this complicates the identification of potential targets for cancer therapy and the evaluation of the effectiveness of these targets.