State a mutant hemoglobin of the beta chain

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A mutant hemoglobin has His146 of the beta chain replaced with a threonine residue. predict what the consequence of this mutation might be. specifically:

(A) would you expect a change in p50? If so, which way?

(B) would you expect a change in cooperativity? If so, which way?

(C) Would you expect a change in DPG binding? If so, which way?

(D) Would you expect the hemoglobin by electrophoresis at pH5? At pH 7?

Reference no: EM13185784

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