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As you continue on in your career, you become keenly interested in the mechanisms of immune cell recruitment during the innate immune response. After years of graduate work, you discovered a new cytokine (X), which chemoattracts neutrophils. In your excitement you begin devising experiments to characterize the function and relevance of cytokine X. From what you know of chemokines, predict the general structure of chemokine X and its cognate receptor.Where, by what cell types, and when would you expect it to be expressed? Explain, experimentally, how you would test your hypothesis.What is the effect of expression of chemokine X on the immune response. Explain, experimentally, how you would test your hypothesis.
As you are working in the lab, you obtain a major career-defining result. You have discovered a new TLR (TLR15), which recognizes either a bacterial or viral antigen. Your task to finish graduate school is to fully characterize the molecule.Design an experiment to determine if your new TLR15 recognizes a bacteria or a virus. What results do you anticipate and what experimental difficulties will you potentially encounter?Comment on the likely structure for the molecule and indicate a plausible signaling pathway for cellular activation.Where in the cell would you expect to find this new TLR? Why? Please design and fully explain two different experiments to test your hypothesis.What are the consequences of deficiency of TLR15? Please design and fully explain two different experiments to test your hypothesis.
Eighteen museum specimens of the extinct great Auk were used to amplify coxI, a mitochondrial gene for cytochrome oxidase. DNA sequence analysis of 600 nucleotides of coxI revealed 5 alleles and the number of nucleotide differences between them are s..
Determine what makes a molecule a hydrogen bond donor or an acceptor? Can a hydrogen on a carbon atom be a hydrogen bond donor? Explain your answer.
Elucidate how at least three organ systems are affected by this increased physical activity and discuss interactions among these systems.
Is a catalase test perfromed on colonies from a BAP? State reasons to support your answer.
What type of compensation plan will you recommend? What are some of the problems you want to be aware of. Develop new coating methods and new applications of coating.
We are isolating DNA from a Marcian. THeir DNA turns out to be very very tiny, so we will use a very dense agarose gel to analyze the DNA. So, instead of the one percent agarose gels that we normally would use in lab,
An eighty nine year old woman has a long history of systolic heart failure that resulted in a large left ventricular infarct when she was in her 70s.
Make an equation describe the relationship between DeltaG, equilibrium constant and prevailing concentrations of substrates and products of reactions.
Diversity in tropical regions is generally greater than at high latitudes. Explain two different hypotheses that propose the mechanism for this pattern that remains a biological mystery
A transmembrane protein in outer membrane of the nuclear envelope would least likely be found later in which one of the following cellular locations?
Determine which intracellular change is the most contributor to increases in fiber size of cross-sectional area and strength?
During the Calvin-Benson cycle, in the red Columbine plant, high-energy electrons are transferred into a newly made three carbon compound.
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