Reference no: EM131373974
Malformations in the lymphatic system, called lymphangiomas, are overgrowths of the one-way lymph channels. Rarely, in infants and children, these channels grow abnormally large and cause deformity or death if the overgrowth chokes off a child's airway or interferes with other aspects of heart and lung function. The deformity tends to grow with the child, worsening over time and is difficult to treat.
Physicians at Lucile Packard Children's Hospital at Stanford discovered, essentially by accident, that a common drug - sildenafil, a.k.a. Viagra - appears to shrink the overgrown vessels. They gave sildenafil to a child with a severe lymphangioma to treat another condition, pulmonary hypertension, and noticed that the lymph malformation shrank significantly. Unfortunately, the child's underlying condition was so severe that she later died; however, two subsequent patients have done well on the medication.
"There has been no medical treatment for lymphangiomas; now all of a sudden there may be one," said Al Lane, MD, a co-author on the NEJM letter published January 2012 and an investigator on the lymphangioma research now being conducted. The mechanism by which the drug could resolve the malformations is not known, however there's a possibility that sildenafil may help to open and drain the channels," Lane said.
The drug (Viagra) has been used to treat pulmonary hypertension in children. Its typical side effects in children are nausea, headaches and cold-like symptoms such as a runny nose or fever, Lane said. Spontaneous erections are possible but are an infrequent side effect. Discuss your thoughts on studying and utilizing Viagra as treatment for lymphangioma and its side effects in children.
Source: Lane, A. (2012, January 26). Sildenfil for Severe Lymphatic Malformations. New England Journal of Medicine, 366. Retrieved from: https://www.nejm.org/doi/full/10.1056/NEJMc1112482
Describe two features any of the ornithopod dinosaurs
: Name and describe two features any of the Ornithopod Dinosaurs had that helped them eat plants. Explain how that feature would help them eat plants.
|
What is the definition of genre
: What is the definition of genre, according to the scholars that Dirk quotes (Lloyd Bitzer, Amy Devitt, and Carolyn Miller)? What two things do you need to identify in a text in order to understand its genre
|
Discuss the possible implications of such a development
: How do the Internet and the associated World Wide Web affect international business activity and the globalization of the world economy?
|
How can you combine two tables or views together
: What is a join command? In addition, How can you combine two tables/views together? For instance one table contains 100 rows and the other one contains 200 rows, have exactly the same fields and you want to show a query with all data (300 rows).
|
Sildenfil for severe lymphatic malformations
: The drug (Viagra) has been used to treat pulmonary hypertension in children. Its typical side effects in children are nausea, headaches and cold-like symptoms such as a runny nose or fever, Lane said. Spontaneous erections are possible but are an ..
|
Who benefits from globalization of flat panel display
: Why is the manufacturing of flat panel TVs migrating to different locations around the world?- Who benefits from the globalization of the flat panel display industry? Who are the losers?
|
Disease or condition researchers are attempting to treat
: Choose one modern example of gene therapy (since 2005), describe the disease or condition researchers are attempting to treat, and explain how the therapy might repair the underlying cause of the disease.
|
What technology was the most difficult to live without
: Prepare a one-to-two page paper that addresses the following questions: What did you learn from your experience? What technology was the most difficult to live without
|
Development of a human-powered vehicle
: Solid Mechanics - development of a Human-Powered Vehicle (HPV) that will attempt to break the HPV world speed record. For this assignment you are set a challenge to optimise the design of Glen's bicycle crank, using commercial finite element analy..
|