Significantly increased risk of post-partum hemorrhage

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Reference no: EM133747292

Summarize key points: Gestational exposure to SsRis associated with significantly increased risk of post-partum hemorrhage (PPH), although increase is smaller than that associated with obstetric risk factors for PPH. That said, precautionary measures should be taken, such as administration of a uterotonic agent immediately after delivery to all women who have received SSRI treatment during the month preceding delivery and close monitoring for continued blood loss for the first 24 h following delivery

• Despite extensive studies on the effects of SRIs in pregnancy, conflicting views on possible adverse effects on the course of pregnancy and on the newborn remain, likely because of the complex and confounding role of factors such as maternal illness itself and stress. Additionally, because depression in late pregnancy is a major predictor for potentially life-threatening postpartum depression, it is advisable to weigh the benefits of treatment against possible hazards. Overall, the consistent message at this time is that this is an individualized decision, but the risk associated with treatment discontinuation in those at high risk of relapse seems to outweigh the potential risks, as severe maternal illness may negatively affect the child's development (12)

• Teratogenicity - accumulating evidence suggests a generally small risk of.

Reference no: EM133747292

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