Sickle cell trait and sickle cell disease

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Use the following information to answer the next two questions.

Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces hemoglobin that sticks together and causes red blood cells to sickle. Heterozygous indivuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell anemia and are described as having the sickle cell trait. Individuals that are homozygous for the sickle allele (HbSHbS) only produce "sickle" hemoglobin and develop sickle cell disease.

Note: Individuals that have sickle cell trait and sickle cell disease have protection against malaria so the HbS allele is higher in areas where malaria is common.

A man who is homozygous for the normal allele married a woman with the sickle cell trait. What is the expected probability of this couple having a boy with the sickle cell trait?

Record your answer as a value between 0 and 1 rounded to two decimal places.

Reference no: EM132955001

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